In 2009, after she had divorced Brown, she told Oprah Winfrey that her cocaine and marijuana use took over her life. Both drugs were found in Houston's system after she died, though the marijuana and several other prescription drugs played no role in her death, coroner's officials said.
"I had so much money and so much access to what I wanted," Houston told Winfrey. "I didn't think about the singing part anymore. I was looking for my young womanhood."
Houston's planned comeback after that interview didn't pan out, but she was taking another shot this year with her appearance in a remake of the film "Sparkle."
She stars as the mother of a family of girls who form a singing group and struggle with fame and addiction. She also sang for the film, delivering a soulful rendition of the gospel hymn "His Eye is on the Sparrow."
It is unclear what impact, if any, the autopsy results will have on the film, although untimely death has not been an impediment to the posthumous releases of other actors and entertainers. Heath Ledger's performance in "The Dark Knight" helped propel the film to blockbuster status and earned the actor a posthumous Oscar. He died of an accidental prescription drug overdose in January 2008, months before the film's release.