The Packers rallied from a 16-point deficit in the fourth quarter, and pulled within eight points when Aaron Rodgers threw a touchdown pass to James Jones with 6:05 left, but the 49ers defense held the Packers in the final minute to come away with a big win to open the season.
Randall Cobb's 75-yard punt return for a touchdown and a 2-point conversion early in the fourth quarter cut the 49ers lead to 23-15. But Rodgers threw an interception to linebacker NaVorro Bowman and Frank Gore ran for a 23-yard touchdown.
David Akers tied an NFL record when he kicked a 63-yard field goal to the end the first half, with the ball bouncing off the crossbar and going through the uprights.
Redskins 40, Saints 32
NEW ORLEANS (AP) — Robert Griffin III began his NFL career by connecting on 19 of 26 passes for 320 yards and two touchdowns, and the Washington Redskins handed the Saints a 40-32 loss in their first game since the bounty scandal that overshadowed New Orleans' offseason.
Griffin completed his first eight passes, including an 88-yard touchdown pass to Pierre Garcon, tying for the second-longest scoring pass by a quarterback making his NFL debut.
Rookie running back Alfred Morris rushed for 96 yards and two touchdowns. Aldrick Robinson, making his NFL debut, had a touchdown catch among four receptions for 52 yards.