Bears 41, Colts 21
CHICAGO (AP) — Jay Cutler threw for 333 yards and two touchdowns and Michael Bush added a pair of scoring runs to spoil quarterback Andrew Luck's debut.
Brandon Marshall had nine catches for 119 yards and a touchdown in his first game since being reunited with Cutler, and Matt Forte ran for 80 yards and a score.
Luck finished his first NFL game 23 of 45 for 309 yards with a 4-yard touchdown pass to Donnie Avery early in the fourth quarter. He also was intercepted three times — twice by Tim Jennings — in an up-and-down effort as he steps in for the departed Peyton Manning.
Reggie Wayne caught nine passes for 135 yards. But it was a familiar result for a team with new management and a new coach in Chuck Pagano.
Eagles 17, Browns 16
CLEVELAND (AP) — Michael Vick overcame four interceptions by throwing a 4-yard touchdown pass to Clay Harbor with 1:18 left in the nerve-racking win.