Lions 27, Rams 23
Stafford made up for a shaky game by leading an 80-yard, nine-play, game-winning possession that included three passes of at least 18 yards.
Sam Bradford directed a go-ahead drive that set up Greg Zuerlein's 46-yard field goal and put the Rams ahead 23-20 with 1:55 left. But coach Jeff Fisher's debut ended with a loss because the Rams could not shut down Stafford in the end.
Stafford had three interceptions before halftime for the first time in his four seasons. Cortland Finnegan had a 31-yard interception return for a TD that gave the Rams a 13-7 lead late in the first half.
Jets 48, Bills 28
The Jets sprinkled in their wildcat package with Tim Tebow, who was mostly quiet but recovered a late onside kick by Buffalo, and Jeremy Kerley had a touchdown catch and a punt return for a score. Antonio Cromartie also took one of New York's three interceptions of Ryan Fitzpatrick to the end zone.