The seat, currently occupied by outgoing Republican Senator Mel Martinez, is up for grabs, and Crist may represent the GOP's best chance for keeping it red. Even if Crist crossed party lines last February to endorse President Obama's stimulus package.
It's all about working together, Crist says
"Here in Florida, we've shown that when we put people first and work together much can be accomplished, and I intend to bring that same approach to Washington," Crist said in a statement announcing his run.
But that approach doesn't work according to his primary opponent, House Speaker Marco Rubio -- who you could call the anti-Crist. (We're here all week, try the veal).
Only hours after Crist's announcement, Rubio's campaign released a web ad which previews one of the ways he'll try to differentiate himself from the popular governor.