2. West Region: (13) Morehead State 62, (4) Louisville 61
The first major upset of the tournament came in Denver on Thursday when Morehead State, the No. 13 seed, toppled in-state foe and No. 4 seed Louisville, 62-61, on Demonte Harper’s 3-pointer with less than 10 seconds left on the clock (it was his only made 3-pointer in five attempts).