Such a strike or strikes would fit Israel's policy of pre-emptive covert and overt action to curb Hezbollah and does not necessarily indicate a major escalation of the war in Syria. It does, however, indicate how the erosion of the Assad family's rule after 42 years is seen by Israel as posing a threat.
Israel this week echoed concerns in the United States about Syrian chemical weapons, but its officials say a more immediate worry is that the civil war could see weapons that are capable of denting its massive superiority in airpower and tanks reaching Hezbollah; the group fought Israel in 2006 and remains a more pressing threat than its Syrian and Iranian sponsors.
Israeli officials have said they feared Assad may be losing his grip on some chemical weapons, including around Damascus, to rebel groups which are also potentially hostile to Israel. U.S. and European security sources told Reuters they were confident that chemical weapons were not in the convoy which was bombed.
Wednesday's action could have been a rapid response to an opportunity. But a stream of Israeli comment on Syria in recent days may have been intended to limit surprise in world capitals.
The head of the Israeli air force said only hours before the attack that his corps, which has an array of the latest jet bombers, attack helicopters and unmanned drones at its disposal, was involved in a covert "campaign between wars".
"This campaign is 24/7, 365 days a year," Major-General Amir Eshel told a conference on Tuesday. "We are taking action to reduce the immediate threats, to create better conditions in which we will be able to win the wars, when they happen."
In Israel, where media operate under military censorship, broadcasters immediately relayed international reports of the strike. Channel Two television quoted what it called foreign sources saying the convoy was carrying anti-aircraft missiles.