Amanda Knox during an interview on the 'Today' show, Sept. 20, 2013 in New York. Knox defended her decision not to return to Italy for a new appeals trial over the 2007 killing of her British roommate, 21-year-old Meredith Kercher, even as she acknowledged that 'everything is at stake,' insisting she is innocent. In March, Italy's supreme court ordered a new trial for Knox and her former Italian boyfriend. An appeals court in 2011 had acquitted both, overturning convictions by a lower court. Italian law cannot compel Knox to return for the new legal proceeding.