"He's not suited for this," said Orlowski, 46. "It wasn't funny."
Sheen's publicist, Larry Solters, declined to comment after the show. Sheen, 45, reappeared after the house lights went up to thank the hundreds who remained.
It wasn't clear when Sheen lost the audience, but there were many awkward moments.
Sheen, known for his wild partying and rampant drug use, said he thought Detroit would be a good place to tell some stories about crack cocaine. The remark prompted loud, immediate boos.
At another point, Sheen showed a short film he wrote, directed and produced years ago called "RPG." He sat in the front row to watch the flick, which starred a much younger Johnny Depp. Again, more boos.
But the show actually started off with a bang.
After a video montage of movie clips — Sheen in "Wall Street" and "Platoon" set to a guitar solo from Sheenfriend Rob Patterson — the star emerged to raucous applause and a standing ovation. The cheering increased as the women he calls his "goddesses" took the stage.
The two women, a former porn star and an actress who live with him, carried placards with the words "War" and "Lock," a reference to Sheen's recent description of himself.