The four movies combined to keep Hollywood in the money compared to the same weekend last year, when "Transformers: Dark of the Moon" launched with $97.9 million.
"Ted's" opening was the third-highest R-rated comedy debut, behind last year's "Hangover 2" ($85.9 million) and 2010's "Sex and the City 2" ($57 million), but it was the biggest ever R-rated non-sequel comedy opening.
It was an equally big weekend overseas, where two huge franchises got a head-start on their U.S. openings.
The 20th Century Fox animated sequel "Ice Age: Continental Drift" opened with $78 million in 34 international markets, while Sony's "The Amazing Spider-Man" debuted with $50.2 million in 13 markets. "Amazing Spider-Man" opens domestically Tuesday for the Fourth of July weekend, while "Continental Drift" has its U.S. debut July 13.
Domestic revenues totaled $207.7 million, up 3 percent from the same weekend in 2011, according to box-office tracker Hollywood.com. That was quite an accomplishment, considering the Fourth of July fell on Monday last year, making it a long holiday weekend.