A message sent to Quvenzhane's representative seeking comment wasn't immediately returned Monday. She was the youngest-ever actress nominee at the Academy Awards.
The Onion's original tweet brought some calls for the fake news organization to publicly identify the writer of the tweet, vows to refuse to retweet its material, and requests from outraged consumers to email The Onion to complain.
Oscar host Seth MacFarlane also joked about the young star during the ceremony. Some found the quip offensive, albeit not to the degree of the outrage over The Onion's tweet. MacFarlane joked that "it'll be 16 years before she's too old for" George Clooney.
Despite the attack, Quvenzhane had some reason to stay positive Sunday. By the time she'd arrived at the Oscar telecast, she could boast that she had been cast to play Annie in a contemporized adaptation of the Broadway musical and the "Little Orphan Annie" comic strip to be directed by Will Gluck.
It wasn't the first time The Onion has gotten into hot water for trying to push its humor. Last year, the site attracted public ire for an image that showed an airliner about to crash into Chicago's Willis Tower. Despite an outcry, the Onion's marketing director refused to back down.
Last year, the joke site made international headlines when the online version of China's Communist Party newspaper hailed an Onion report naming North Korean dictator Kim Jong Un as the "Sexiest Man Alive" — apparently unaware it was satire.