4. Peyton Manning
With 141 regular season victories, Peyton Manning is fourth all-time on our list. Beginning in 1998, Manning has thrown for 54,828 yards and 399 touchdowns in his career. He led the Indianapolis Colts to Super Bowl appearances after the 2006 and 2009 NFL seasons, with a victory over the Chicago Bears in Super Bowl XLI. Manning has four NFL MVPs, and six AFC Player of the Year awards. Like Tom Brady, most expect Manning to reach the Hall of Fame in Canton, Ohio, after retirement.