The Texas Rangers outfielder drove in eight runs with four swings of the bat Tuesday night.
Hamilton hit three of the blasts to center field and one to left off three different Oriole pitchers at Camden Yards. All the home runs were two-run shots. He ended up going five-for-five at the plate, adding a fifth-inning double.
The Rangers center fielder enjoyed how his teammates reacted as much as hitting the home runs, ESPN.com reported.
"I was saying after I hit two that I had never hit three in a game before. What a blessing that was," Hamilton said. "And then to hit four, it was just an awesome feeling to see how excited my teammates got.
"It reminds you of when you're in Little League and a little kid, and just the excitement and why we play the game. Things like that. You never know what can happen. It was just an absolute blessing."